Think faster voltage gives you sharper bands?

Not so fast!
What appears to be a time-saving shortcut during electrophoresis could actually distort your results. Running a gel at a high voltage not only speeds up migration but also warps the electric field across the gel, causing ions to flow unevenly. The result? Bands that smile back at you.

We've created a brief explanation that reveals the true cause of this common artefact and why it is not related to overheating, buffer evaporation, or DNA denaturation.

💡 Curious why voltage matters more than you think?